Placebo in clinical trials
نویسندگان
چکیده
منابع مشابه
The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials – A secondary analysis
BACKGROUND AND PURPOSE Placebo response rates in clinical trials vary considerably and are observed frequently. For new drugs it can be difficult to prove effectiveness superior to placebo. It is unclear what contributes to improvement in the placebo groups. We wanted to clarify, what elements of clinical trials determine placebo variability. METHODS We analysed a representative sample of 141...
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The objective was to assess the placebo response in randomized clinical trials of analgesics in the treatment of migraine attacks. We included placebo-controlled studies that used the criteria of the International Headache Society for the diagnosis of migraine and headache response as the primary efficacy parameter. In the 11 studies that qualified for inclusion, headache response occurred afte...
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In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملThe placebo effect in early-phase glaucoma clinical trials.
PURPOSE To analyze the extent and prevalence of the placebo effect in prior early-phase glaucoma clinical studies. METHODS Articles were evaluated on phase I and II trials of glaucoma medicines that became commercially available after 1977 with a placebo arm that involved glaucoma patients. RESULTS We included 23 studies with 23 treatment arms with a total of 1703 patients in articles evalu...
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Meta-analyses and re-analyses of trial data have not been able to answer some of the essential questions that would allow prediction of placebo responses in clinical trials. We will confront these questions with current empirical evidence. The most important question asks whether the placebo response rates in the drug arm and in the placebo arm are equal. This 'additive model' is a general assu...
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ژورنال
عنوان ژورنال: Perspectives in Clinical Research
سال: 2013
ISSN: 2229-3485
DOI: 10.4103/2229-3485.106383